The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site
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چکیده
منابع مشابه
Mechanism of 150-cavity formation in influenza neuraminidase
The recently discovered 150-cavity in the active site of group-1 influenza A neuraminidase (NA) proteins provides a target for rational structure-based drug development to counter the increasing frequency of antiviral resistance in influenza. Surprisingly, the 2009 H1N1 pandemic virus (09N1) neuraminidase was crystalized without the 150-cavity characteristic of group-1 NAs. Here we demonstrate,...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2010
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.1909